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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: many challenges in developing efficient and target specific delivery systems of small molecule and nucleicacid drugs.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: X-ray crystallography is a powerful strategy for 3-D structure determination of macromolecules, such as nucleicacids and protein-nucleic acid complexes.Recently we have successfully developed synthesis and strategy of selenium-derivatized nucleic acids(SeNA) for nucleic acid crystallography.

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assistedAcetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared tostudy the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media.In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: Polymer-based conjugates are an interesting option and challenge for the design of nano-sized drug-deliveryIn the case of nucleic acid therapy, non-viral carriers face several biological barriers during the deliveryengineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleicacid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 203-212 doi: 10.1007/s11705-016-1572-4

Abstract: Modeling structural and thermodynamic properties of nucleic acids has long been a challenge in the developmenthave been proved to be reliable to model small molecules, polypeptides and proteins, but their use on nucleicIn this article, the interactions between nucleic acids and a small molecule or ion were modeled by AMOEBAbio09

Keywords： nucleic acid     polarizable force field     AMOEBA    

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Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 173-186 doi: 10.1007/s11684-012-0195-5

Abstract: Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequencesHere we review some of the most popular nucleic acid-based diagnostics and focus on their adaptabilityWe also compare and contrast the characteristics of different types of nucleic acid-based diagnostics

Keywords： nucleic acid-based diagnostics     infectious disease     PCR     NASBA     LAMP     microarray     LOAC     public health affairs    

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Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

G. Usha RANI,Kartick Prasad DEY,Srijita BHARTI,Sumit MISHRA

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 465-470 doi: 10.1007/s11705-014-1452-8

Abstract: hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic aciddrug release studies were performed at pH values of 2 and 7 in order to investigate the possibility ofpH triggered release for colon targeted drug delivery.(the time taken for release of 50% of the enclosed drug) value was studied and the results indicate thatit may be possible to develop a programmable drug release matrix based on grafted polysaccharide.

Keywords： agar     controlled drug release     5-Amino salicylic acid     poly(2-hydroxyethylmethacrylate) grafted agar    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: This article first summarizes the R&D status of nucleic acid vaccines from the aspects of relatedacid vaccines.acid vaccines, and studies the possible technical and safety problems.Furthermore, we suggest that the key technologies of nucleic acid vaccines should be developed by improvingMoreover, the safety and efficacy of nucleic acid vaccines should be strictly monitored; stakeholders

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messenger    

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Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0884-4

Abstract: Flow cytometry based on nucleic acid stains and CTC was established and optimized.Chlorine demonstrated stronger and faster destructive effects on cytomembrane than chloramine, and nucleic

Keywords： Flow cytometry     Escherichia coli     Staphylococcusaureus     UV     CTC     SYTO 9    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistantWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drugThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given with

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering     improved     pressure     aqueous     technique    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite     hollow spheres     synthesis     drug release    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugAmino acid changes were identified at nine residues in Pvdhfr.vivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Title Author Date Type Operation

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleicacid drugs: learning from virus

Vaibhav Mundra, Ram I. Mahato

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Validation of polarizable force field parameters for nucleic acids by inter-molecular interactions

Liaoran Cao,Hong Ren,Jing Miao,Wei Guo,Yan Li,Guohui Li

Journal Article

Nucleic acid-based diagnostics for infectious diseases in public health affairs

Albert Cheung-Hoi Yu, Greg Vatcher, Xin Yue, Yan Dong, Mao Hua Li, Patrick H. K. Tam, Parker Y.L. Tsang, April K.Y. Wong, Michael H.K. Hui, Bin Yang, Hao Tang, Lok-Ting Lau

Journal Article

Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

G. Usha RANI,Kartick Prasad DEY,Srijita BHARTI,Sumit MISHRA

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleicacid stains and 5-cyano-2,3-ditolyltetrazolium chloride

Xuebiao Nie, Wenjun Liu, Mo Chen, Minmin Liu, Lu Ao

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Li Aihua: Development Trends and Suggestions of Nucleic Acid Vaccines (2021-9-3)

15 Oct 2021

Conference Videos

Protein microspheres for pulmonary drug delivery

Yongda SUN,

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article